AustralieFrV1, Main, Exploration, bibRecord, 004221

Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease

Identifieur interne : 004221 ( Main/Exploration ); précédent : 004220; suivant : 004222

Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease

Auteurs : Harvey D. White [Nouvelle-Zélande] ; Claes Held [Suède] ; Ralph Stewart [Nouvelle-Zélande] ; Elizabeth Tarka [États-Unis] ; Rebekkah Brown [États-Unis] ; Richard Y. Davies [États-Unis] ; Andrzej Budaj [Pologne] ; Robert A. Harrington [États-Unis] ; P. Gabriel Steg [France, Royaume-Uni] ; Diego Ardissino [Italie] ; Paul W. Armstrong [Canada] ; Alvaro Avezum [Brésil] ; Philip E. Aylward [Australie] ; Alfonso Bryce [Pérou] ; HONG CHEN [République populaire de Chine] ; Ming-Fong Chen [Taïwan] ; Ramon Corbalan [Chili] ; Anthony J. Dalby [Afrique du Sud] ; Nicolas Danchin [France] ; Robbert J. De Winter [Pays-Bas] ; Stefan Denchev [Bulgarie] ; Rafael Diaz ; Moses Elisaf ; Marcus D. Flather ; Assen R. Goudev [Bulgarie] ; Christopher B. Granger [États-Unis] ; Liliana Grinfeld ; Judith S. Hochman ; Steen Husted ; Hyo-Soo Kim ; WOLFGANG KOENIG ; Ales Linhart ; Eva Lonn [Canada] ; José Lopez-Sendon ; Athanasios J. Manolis ; Emile R. Iii Mohler ; José C. Nicolau [Brésil] ; Prem Pais ; Alexander Parkhomenko ; Terje R. Pedersen ; Daniel Pella ; Marco A. Ramos-Corrales ; Mikhail Ruda ; Mátyás Sereg ; Saulat Siddique ; Peter Sinnaeve ; Peter Smith [États-Unis] ; Piyamitr Sritara ; Henk P. Swart ; Rody G. Sy ; Tamio Teramoto ; Hung-Fat Tse ; David Watson [États-Unis] ; W. Douglas Weaver ; Robert Weiss ; Margus Viigimaa ; Dragos Vinereanu ; JUNREN ZHU ; Christopher P. Cannon

Source :

The New England journal of medicine [ 0028-4793 ] ; 2014.

RBID : Pascal:14-0105569

Descripteurs français

Pascal (Inist)
- Ischémie, Cardiopathie coronaire, Darapladib, Prévention, Médecine.
Wicri :
- topic : Médecine.

English descriptors

KwdEn :
- Coronary heart disease, Darapladib, Ischemia, Medicine, Prevention.

Abstract

BACKGROUND Elevated lipoprotein-associated phospholipase A₂ activity promotes the development of vulnerable atherosclerotic plaques, and elevated plasma levels of this enzyme are associated with an increased risk of coronary events. Darapladib is a selective oral inhibitor of lipoprotein-associated phospholipase A₂. METHODS In a double-blind trial, we randomly assigned 15,828 patients with stable coronary heart disease to receive either once-daily darapladib (at a dose of 160 mg) or placebo. The primary end point was the time to cardiovascular death, myocardial infarction, or stroke. Secondary end points included the components of the primary end point as well as major coronary events (death from coronary heart disease, myocardial infarction, or urgent coronary revascularization for myocardial ischemia) and total coronary events (death from coronary heart disease, myocardial infarction, hospitalization for unstable angina, or any coronary revascularization). RESULTS During a median follow-up period of 3.7 years, the primary end point occurred in 769 of 7924 patients (9.7%) in the darapladib group and 819 of 7904 patients (10.4%) in the placebo group (hazard ratio in the darapladib group, 0.94; 95% confidence interval [CI], 0.85 to 1.03; P=0.20).

Affiliations:

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Le document en format XML

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<author><name sortKey="Swart, Henk P" sort="Swart, Henk P" uniqKey="Swart H" first="Henk P." last="Swart">Henk P. Swart</name>
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<author><name sortKey="Sy, Rody G" sort="Sy, Rody G" uniqKey="Sy R" first="Rody G." last="Sy">Rody G. Sy</name>
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<author><name sortKey="Teramoto, Tamio" sort="Teramoto, Tamio" uniqKey="Teramoto T" first="Tamio" last="Teramoto">Tamio Teramoto</name>
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<author><name sortKey="Tse, Hung Fat" sort="Tse, Hung Fat" uniqKey="Tse H" first="Hung-Fat" last="Tse">Hung-Fat Tse</name>
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<author><name sortKey="Watson, David" sort="Watson, David" uniqKey="Watson D" first="David" last="Watson">David Watson</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKlineResearch Triangle Park</s1>
<s2>North Carolina</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>47 aut.</sZ>
<sZ>53 aut.</sZ>
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<country>États-Unis</country>
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</placeName>
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<author><name sortKey="Weaver, W Douglas" sort="Weaver, W Douglas" uniqKey="Weaver W" first="W. Douglas" last="Weaver">W. Douglas Weaver</name>
</author>
<author><name sortKey="Weiss, Robert" sort="Weiss, Robert" uniqKey="Weiss R" first="Robert" last="Weiss">Robert Weiss</name>
</author>
<author><name sortKey="Viigimaa, Margus" sort="Viigimaa, Margus" uniqKey="Viigimaa M" first="Margus" last="Viigimaa">Margus Viigimaa</name>
</author>
<author><name sortKey="Vinereanu, Dragos" sort="Vinereanu, Dragos" uniqKey="Vinereanu D" first="Dragos" last="Vinereanu">Dragos Vinereanu</name>
</author>
<author><name sortKey="Junren Zhu" sort="Junren Zhu" uniqKey="Junren Zhu" last="Junren Zhu">JUNREN ZHU</name>
</author>
<author><name sortKey="Cannon, Christopher P" sort="Cannon, Christopher P" uniqKey="Cannon C" first="Christopher P." last="Cannon">Christopher P. Cannon</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease</title>
<author><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland</s1>
<s2>Auckland</s2>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
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</affiliation>
</author>
<author><name sortKey="Held, Claes" sort="Held, Claes" uniqKey="Held C" first="Claes" last="Held">Claes Held</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medical Sciences, Cardiology, Uppsala University, and Uppsala Clinical Research Center</s1>
<s2>Uppsala</s2>
<s3>SWE</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Uppsala</wicri:noRegion>
<orgName type="university">Université d'Uppsala</orgName>
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<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stewart, Ralph" sort="Stewart, Ralph" uniqKey="Stewart R" first="Ralph" last="Stewart">Ralph Stewart</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland</s1>
<s2>Auckland</s2>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tarka, Elizabeth" sort="Tarka, Elizabeth" uniqKey="Tarka E" first="Elizabeth" last="Tarka">Elizabeth Tarka</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia</s1>
<s2>PA</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
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<country>États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Brown, Rebekkah" sort="Brown, Rebekkah" uniqKey="Brown R" first="Rebekkah" last="Brown">Rebekkah Brown</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKlineResearch Triangle Park</s1>
<s2>North Carolina</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>47 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
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<author><name sortKey="Davies, Richard Y" sort="Davies, Richard Y" uniqKey="Davies R" first="Richard Y." last="Davies">Richard Y. Davies</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia</s1>
<s2>PA</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Budaj, Andrzej" sort="Budaj, Andrzej" uniqKey="Budaj A" first="Andrzej" last="Budaj">Andrzej Budaj</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Postgraduate Medical School, Grochowski Hospital</s1>
<s2>Warsaw</s2>
<s3>POL</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pologne</country>
<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harrington, Robert A" sort="Harrington, Robert A" uniqKey="Harrington R" first="Robert A." last="Harrington">Robert A. Harrington</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Medicine, Stanford University</s1>
<s2>Stanford, CA</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Steg, P Gabriel" sort="Steg, P Gabriel" uniqKey="Steg P" first="P. Gabriel" last="Steg">P. Gabriel Steg</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>INSERM Unité 1148, Assistance Publique-Hôpitaux de Paris, Département Hospitalo-Universitaire FIRE, Hôpital Bichat</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Université Paris-Diderot, Sorbonne-Paris Cité</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>NHLI Imperial College, ICMS, Royal Brompton Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ardissino, Diego" sort="Ardissino, Diego" uniqKey="Ardissino D" first="Diego" last="Ardissino">Diego Ardissino</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Azienda Ospedaliero-Universitaria di Parma</s1>
<s2>Parma</s2>
<s3>ITA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Azienda Ospedaliero-Universitaria di Parma</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Armstrong, Paul W" sort="Armstrong, Paul W" uniqKey="Armstrong P" first="Paul W." last="Armstrong">Paul W. Armstrong</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Canadian VIGOUR Centre, University of Alberta</s1>
<s2>Edmonton</s2>
<s3>CAN</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Edmonton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Avezum, Alvaro" sort="Avezum, Alvaro" uniqKey="Avezum A" first="Alvaro" last="Avezum">Alvaro Avezum</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Dante Pazzanese Institute of Cardiology</s1>
<s2>São Paulo</s2>
<s3>BRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Brésil</country>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aylward, Philip E" sort="Aylward, Philip E" uniqKey="Aylward P" first="Philip E." last="Aylward">Philip E. Aylward</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>South Australian Health and Medical Research Institute, Flinders University and Medical Centre</s1>
<s2>Adelaide, SA</s2>
<s3>AUS</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bryce, Alfonso" sort="Bryce, Alfonso" uniqKey="Bryce A" first="Alfonso" last="Bryce">Alfonso Bryce</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Cardiogolf/Clinica El Golf</s1>
<s2>Lima</s2>
<s3>PER</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Pérou</country>
<wicri:noRegion>Cardiogolf/Clinica El Golf</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hong Chen" sort="Hong Chen" uniqKey="Hong Chen" last="Hong Chen">HONG CHEN</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Department of Cardiology, Peking University People's Hospital</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Ming Fong" sort="Chen, Ming Fong" uniqKey="Chen M" first="Ming-Fong" last="Chen">Ming-Fong Chen</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Department of Internal Medicine, National Taiwan University Hospital</s1>
<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Corbalan, Ramon" sort="Corbalan, Ramon" uniqKey="Corbalan R" first="Ramon" last="Corbalan">Ramon Corbalan</name>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Cardiovascular Division Pontificia Universidad Catolica de Chile</s1>
<s2>Santiago</s2>
<s3>CHL</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Chili</country>
<wicri:noRegion>Cardiovascular Division Pontificia Universidad Catolica de Chile</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dalby, Anthony J" sort="Dalby, Anthony J" uniqKey="Dalby A" first="Anthony J." last="Dalby">Anthony J. Dalby</name>
<affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Milpark Hospital</s1>
<s2>Johannesburg</s2>
<s3>ZAF</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Afrique du Sud</country>
<wicri:noRegion>Milpark Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Danchin, Nicolas" sort="Danchin, Nicolas" uniqKey="Danchin N" first="Nicolas" last="Danchin">Nicolas Danchin</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, INSERM Unité 970 and Université Paris Descartes</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
</author>
<author><name sortKey="De Winter, Robbert J" sort="De Winter, Robbert J" uniqKey="De Winter R" first="Robbert J." last="De Winter">Robbert J. De Winter</name>
<affiliation wicri:level="4"><inist:fA14 i1="23"><s1>Department of Cardiology, Academic Medical Center, University of Amsterdam</s1>
<s2>Amsterdam</s2>
<s3>NLD</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author><name sortKey="Denchev, Stefan" sort="Denchev, Stefan" uniqKey="Denchev S" first="Stefan" last="Denchev">Stefan Denchev</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Clinic of Cardiology, University Hospital Alexandrovska</s1>
<s2>Sofia</s2>
<s3>BGR</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Bulgarie</country>
<placeName><settlement type="city">Sofia</settlement>
<region nuts="2">Sofia-ville (oblast)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diaz, Rafael" sort="Diaz, Rafael" uniqKey="Diaz R" first="Rafael" last="Diaz">Rafael Diaz</name>
</author>
<author><name sortKey="Elisaf, Moses" sort="Elisaf, Moses" uniqKey="Elisaf M" first="Moses" last="Elisaf">Moses Elisaf</name>
</author>
<author><name sortKey="Flather, Marcus D" sort="Flather, Marcus D" uniqKey="Flather M" first="Marcus D." last="Flather">Marcus D. Flather</name>
</author>
<author><name sortKey="Goudev, Assen R" sort="Goudev, Assen R" uniqKey="Goudev A" first="Assen R." last="Goudev">Assen R. Goudev</name>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Cardiology Department, Queen Giovanna University Hospital</s1>
<s2>Sofia</s2>
<s3>BGR</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Bulgarie</country>
<placeName><settlement type="city">Sofia</settlement>
<region nuts="2">Sofia-ville (oblast)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Granger, Christopher B" sort="Granger, Christopher B" uniqKey="Granger C" first="Christopher B." last="Granger">Christopher B. Granger</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grinfeld, Liliana" sort="Grinfeld, Liliana" uniqKey="Grinfeld L" first="Liliana" last="Grinfeld">Liliana Grinfeld</name>
</author>
<author><name sortKey="Hochman, Judith S" sort="Hochman, Judith S" uniqKey="Hochman J" first="Judith S." last="Hochman">Judith S. Hochman</name>
</author>
<author><name sortKey="Husted, Steen" sort="Husted, Steen" uniqKey="Husted S" first="Steen" last="Husted">Steen Husted</name>
</author>
<author><name sortKey="Kim, Hyo Soo" sort="Kim, Hyo Soo" uniqKey="Kim H" first="Hyo-Soo" last="Kim">Hyo-Soo Kim</name>
</author>
<author><name sortKey="Wolfgang Koenig" sort="Wolfgang Koenig" uniqKey="Wolfgang Koenig" last="Wolfgang Koenig">WOLFGANG KOENIG</name>
</author>
<author><name sortKey="Linhart, Ales" sort="Linhart, Ales" uniqKey="Linhart A" first="Ales" last="Linhart">Ales Linhart</name>
</author>
<author><name sortKey="Lonn, Eva" sort="Lonn, Eva" uniqKey="Lonn E" first="Eva" last="Lonn">Eva Lonn</name>
<affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Department of Medicine and Population Health Research Institute, McMaster University</s1>
<s2>Hamilton, ON</s2>
<s3>CAN</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Hamilton (Ontario)</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université McMaster</orgName>
</affiliation>
</author>
<author><name sortKey="Lopez Sendon, Jose" sort="Lopez Sendon, Jose" uniqKey="Lopez Sendon J" first="José" last="Lopez-Sendon">José Lopez-Sendon</name>
</author>
<author><name sortKey="Manolis, Athanasios J" sort="Manolis, Athanasios J" uniqKey="Manolis A" first="Athanasios J." last="Manolis">Athanasios J. Manolis</name>
</author>
<author><name sortKey="Mohler, Emile R Iii" sort="Mohler, Emile R Iii" uniqKey="Mohler E" first="Emile R. Iii" last="Mohler">Emile R. Iii Mohler</name>
</author>
<author><name sortKey="Nicolau, Jose C" sort="Nicolau, Jose C" uniqKey="Nicolau J" first="José C." last="Nicolau">José C. Nicolau</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Heart Institute (InCor), University of São Paulo Medical School</s1>
<s2>São Paulo</s2>
<s3>BRA</s3>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Brésil</country>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pais, Prem" sort="Pais, Prem" uniqKey="Pais P" first="Prem" last="Pais">Prem Pais</name>
</author>
<author><name sortKey="Parkhomenko, Alexander" sort="Parkhomenko, Alexander" uniqKey="Parkhomenko A" first="Alexander" last="Parkhomenko">Alexander Parkhomenko</name>
</author>
<author><name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R." last="Pedersen">Terje R. Pedersen</name>
</author>
<author><name sortKey="Pella, Daniel" sort="Pella, Daniel" uniqKey="Pella D" first="Daniel" last="Pella">Daniel Pella</name>
</author>
<author><name sortKey="Ramos Corrales, Marco A" sort="Ramos Corrales, Marco A" uniqKey="Ramos Corrales M" first="Marco A." last="Ramos-Corrales">Marco A. Ramos-Corrales</name>
</author>
<author><name sortKey="Ruda, Mikhail" sort="Ruda, Mikhail" uniqKey="Ruda M" first="Mikhail" last="Ruda">Mikhail Ruda</name>
</author>
<author><name sortKey="Sereg, Matyas" sort="Sereg, Matyas" uniqKey="Sereg M" first="Mátyás" last="Sereg">Mátyás Sereg</name>
</author>
<author><name sortKey="Siddique, Saulat" sort="Siddique, Saulat" uniqKey="Siddique S" first="Saulat" last="Siddique">Saulat Siddique</name>
</author>
<author><name sortKey="Sinnaeve, Peter" sort="Sinnaeve, Peter" uniqKey="Sinnaeve P" first="Peter" last="Sinnaeve">Peter Sinnaeve</name>
</author>
<author><name sortKey="Smith, Peter" sort="Smith, Peter" uniqKey="Smith P" first="Peter" last="Smith">Peter Smith</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKlineResearch Triangle Park</s1>
<s2>North Carolina</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>47 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sritara, Piyamitr" sort="Sritara, Piyamitr" uniqKey="Sritara P" first="Piyamitr" last="Sritara">Piyamitr Sritara</name>
</author>
<author><name sortKey="Swart, Henk P" sort="Swart, Henk P" uniqKey="Swart H" first="Henk P." last="Swart">Henk P. Swart</name>
</author>
<author><name sortKey="Sy, Rody G" sort="Sy, Rody G" uniqKey="Sy R" first="Rody G." last="Sy">Rody G. Sy</name>
</author>
<author><name sortKey="Teramoto, Tamio" sort="Teramoto, Tamio" uniqKey="Teramoto T" first="Tamio" last="Teramoto">Tamio Teramoto</name>
</author>
<author><name sortKey="Tse, Hung Fat" sort="Tse, Hung Fat" uniqKey="Tse H" first="Hung-Fat" last="Tse">Hung-Fat Tse</name>
</author>
<author><name sortKey="Watson, David" sort="Watson, David" uniqKey="Watson D" first="David" last="Watson">David Watson</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKlineResearch Triangle Park</s1>
<s2>North Carolina</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>47 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weaver, W Douglas" sort="Weaver, W Douglas" uniqKey="Weaver W" first="W. Douglas" last="Weaver">W. Douglas Weaver</name>
</author>
<author><name sortKey="Weiss, Robert" sort="Weiss, Robert" uniqKey="Weiss R" first="Robert" last="Weiss">Robert Weiss</name>
</author>
<author><name sortKey="Viigimaa, Margus" sort="Viigimaa, Margus" uniqKey="Viigimaa M" first="Margus" last="Viigimaa">Margus Viigimaa</name>
</author>
<author><name sortKey="Vinereanu, Dragos" sort="Vinereanu, Dragos" uniqKey="Vinereanu D" first="Dragos" last="Vinereanu">Dragos Vinereanu</name>
</author>
<author><name sortKey="Junren Zhu" sort="Junren Zhu" uniqKey="Junren Zhu" last="Junren Zhu">JUNREN ZHU</name>
</author>
<author><name sortKey="Cannon, Christopher P" sort="Cannon, Christopher P" uniqKey="Cannon C" first="Christopher P." last="Cannon">Christopher P. Cannon</name>
</author>
</analytic>
<series><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronary heart disease</term>
<term>Darapladib</term>
<term>Ischemia</term>
<term>Medicine</term>
<term>Prevention</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Ischémie</term>
<term>Cardiopathie coronaire</term>
<term>Darapladib</term>
<term>Prévention</term>
<term>Médecine</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médecine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">BACKGROUND Elevated lipoprotein-associated phospholipase A<sub>2</sub>
 activity promotes the development of vulnerable atherosclerotic plaques, and elevated plasma levels of this enzyme are associated with an increased risk of coronary events. Darapladib is a selective oral inhibitor of lipoprotein-associated phospholipase A<sub>2</sub>
. METHODS In a double-blind trial, we randomly assigned 15,828 patients with stable coronary heart disease to receive either once-daily darapladib (at a dose of 160 mg) or placebo. The primary end point was the time to cardiovascular death, myocardial infarction, or stroke. Secondary end points included the components of the primary end point as well as major coronary events (death from coronary heart disease, myocardial infarction, or urgent coronary revascularization for myocardial ischemia) and total coronary events (death from coronary heart disease, myocardial infarction, hospitalization for unstable angina, or any coronary revascularization). RESULTS During a median follow-up period of 3.7 years, the primary end point occurred in 769 of 7924 patients (9.7%) in the darapladib group and 819 of 7904 patients (10.4%) in the placebo group (hazard ratio in the darapladib group, 0.94; 95% confidence interval [CI], 0.85 to 1.03; P=0.20).</div>
</front>
</TEI>
<affiliations><list><country><li>Afrique du Sud</li>
<li>Australie</li>
<li>Brésil</li>
<li>Bulgarie</li>
<li>Canada</li>
<li>Chili</li>
<li>France</li>
<li>Italie</li>
<li>Nouvelle-Zélande</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Pérou</li>
<li>Royaume-Uni</li>
<li>République populaire de Chine</li>
<li>Suède</li>
<li>Taïwan</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Caroline du Nord</li>
<li>East Middle Sweden</li>
<li>Grand Londres</li>
<li>Hollande-Septentrionale</li>
<li>Ontario</li>
<li>Sofia-ville (oblast)</li>
<li>Svealand</li>
<li>État de São Paulo</li>
<li>Île-de-France</li>
</region>
<settlement><li>Amsterdam</li>
<li>Hamilton (Ontario)</li>
<li>Londres</li>
<li>Paris</li>
<li>Pékin</li>
<li>Sofia</li>
<li>São Paulo</li>
<li>Uppsala</li>
</settlement>
<orgName><li>Université McMaster</li>
<li>Université Paris-Descartes</li>
<li>Université d'Amsterdam</li>
<li>Université d'Uppsala</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Cannon, Christopher P" sort="Cannon, Christopher P" uniqKey="Cannon C" first="Christopher P." last="Cannon">Christopher P. Cannon</name>
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<name sortKey="Husted, Steen" sort="Husted, Steen" uniqKey="Husted S" first="Steen" last="Husted">Steen Husted</name>
<name sortKey="Junren Zhu" sort="Junren Zhu" uniqKey="Junren Zhu" last="Junren Zhu">JUNREN ZHU</name>
<name sortKey="Kim, Hyo Soo" sort="Kim, Hyo Soo" uniqKey="Kim H" first="Hyo-Soo" last="Kim">Hyo-Soo Kim</name>
<name sortKey="Linhart, Ales" sort="Linhart, Ales" uniqKey="Linhart A" first="Ales" last="Linhart">Ales Linhart</name>
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<name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R." last="Pedersen">Terje R. Pedersen</name>
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<name sortKey="Sereg, Matyas" sort="Sereg, Matyas" uniqKey="Sereg M" first="Mátyás" last="Sereg">Mátyás Sereg</name>
<name sortKey="Siddique, Saulat" sort="Siddique, Saulat" uniqKey="Siddique S" first="Saulat" last="Siddique">Saulat Siddique</name>
<name sortKey="Sinnaeve, Peter" sort="Sinnaeve, Peter" uniqKey="Sinnaeve P" first="Peter" last="Sinnaeve">Peter Sinnaeve</name>
<name sortKey="Sritara, Piyamitr" sort="Sritara, Piyamitr" uniqKey="Sritara P" first="Piyamitr" last="Sritara">Piyamitr Sritara</name>
<name sortKey="Swart, Henk P" sort="Swart, Henk P" uniqKey="Swart H" first="Henk P." last="Swart">Henk P. Swart</name>
<name sortKey="Sy, Rody G" sort="Sy, Rody G" uniqKey="Sy R" first="Rody G." last="Sy">Rody G. Sy</name>
<name sortKey="Teramoto, Tamio" sort="Teramoto, Tamio" uniqKey="Teramoto T" first="Tamio" last="Teramoto">Tamio Teramoto</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Steg, P Gabriel" sort="Steg, P Gabriel" uniqKey="Steg P" first="P. Gabriel" last="Steg">P. Gabriel Steg</name>
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<name sortKey="Danchin, Nicolas" sort="Danchin, Nicolas" uniqKey="Danchin N" first="Nicolas" last="Danchin">Nicolas Danchin</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Steg, P Gabriel" sort="Steg, P Gabriel" uniqKey="Steg P" first="P. Gabriel" last="Steg">P. Gabriel Steg</name>
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<country name="Canada"><noRegion><name sortKey="Armstrong, Paul W" sort="Armstrong, Paul W" uniqKey="Armstrong P" first="Paul W." last="Armstrong">Paul W. Armstrong</name>
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<name sortKey="Lonn, Eva" sort="Lonn, Eva" uniqKey="Lonn E" first="Eva" last="Lonn">Eva Lonn</name>
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<country name="Brésil"><region name="État de São Paulo"><name sortKey="Avezum, Alvaro" sort="Avezum, Alvaro" uniqKey="Avezum A" first="Alvaro" last="Avezum">Alvaro Avezum</name>
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<name sortKey="Nicolau, Jose C" sort="Nicolau, Jose C" uniqKey="Nicolau J" first="José C." last="Nicolau">José C. Nicolau</name>
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<country name="Australie"><noRegion><name sortKey="Aylward, Philip E" sort="Aylward, Philip E" uniqKey="Aylward P" first="Philip E." last="Aylward">Philip E. Aylward</name>
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<country name="Pérou"><noRegion><name sortKey="Bryce, Alfonso" sort="Bryce, Alfonso" uniqKey="Bryce A" first="Alfonso" last="Bryce">Alfonso Bryce</name>
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<country name="Taïwan"><noRegion><name sortKey="Chen, Ming Fong" sort="Chen, Ming Fong" uniqKey="Chen M" first="Ming-Fong" last="Chen">Ming-Fong Chen</name>
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<country name="Chili"><noRegion><name sortKey="Corbalan, Ramon" sort="Corbalan, Ramon" uniqKey="Corbalan R" first="Ramon" last="Corbalan">Ramon Corbalan</name>
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<country name="Afrique du Sud"><noRegion><name sortKey="Dalby, Anthony J" sort="Dalby, Anthony J" uniqKey="Dalby A" first="Anthony J." last="Dalby">Anthony J. Dalby</name>
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<name sortKey="Goudev, Assen R" sort="Goudev, Assen R" uniqKey="Goudev A" first="Assen R." last="Goudev">Assen R. Goudev</name>
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</affiliations>
</record>

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Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease

Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease

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